At Renovation Advanced Therapy Center procedures are performed using some of the most scientifically advanced facilities in the world.
Most Kidney Failure patients can be helped with Stem Cell from adipose tissue or/and human umbilical cord tissue-derived mesenchymal stem cells.
Typically this is an outpatient procedure, however, patients may stay for 2 or 3 nights in our facilities.
About Kidney Failure
Kidney failure (or renal failure) is a condition in which the kidneys fail to function properly.
Physiologically, renal failure is described as a decrease in blood filtration (glomerular filtration rate or GFR). Clinically, this is manifested in elevated serum creatinine. Still not well understood are many of the factors that are involved in kidney failure. Researchers are studying the effects of nutritional proteins and the concentration of cholesterol in the blood.
Acute renal failure: Some kidney problems happen quickly, such as from an accident that causes kidney damage. A great loss of blood can cause sudden kidney failure, also some drugs or poisons can cause the kidneys to stop working. Such sudden drops in kidney function are called acute renal failure.
Symptoms of Kidney Failure
Acute renal failure (ARF) is, as its name implies, a rapidly progressive loss of renal function, generally characterized by oliguria, a decreased urine production (measured as less than 400 mL per day for adults, less than 0.5 mL/kg/hour in children, or less than 1 mL/kg/hour in infants), and water imbalance of body fluids and electrolyte disorders.
Chronic renal failure (CRF) is the condition that is caused by permanent and irreversible damage to kidney function, secondary to any cause. Worldwide, the most common causes (but not the only) of chronic kidney disease include diabetes, hypertension, and obstructive diseases of the urinary tract (such as stones, tumors, etc.). It can arise from the complication of a large number of kidney diseases such as IgA nephropathy (Berger’s disease), inflammatory diseases of the kidney (glomerulonephritis), chronic pyelonephritis and urinary retention, and the use of toxic drugs to the kidney (particularly contrast media and some antibiotics). Terminal renal failure is the ultimate result, which usually requires dialysis until a donor can be found for a kidney transplant.
If the disease is detected early, the speed with which the damage progresses can be slowed, delaying the onset of replacement therapies and giving the patient more time to prepare for such therapy. Currently available renal replacement therapies are hemodialysis, peritoneal dialysis, and renal transplantation.
Causes of Kidney Failure
In the United States, about 80,000 people are diagnosed with kidney failure each year. This is a serious condition. Diabetes is the most common cause of kidney failure and constitutes more than forty percent of new cases. Even when drugs and diet can control diabetes, the disease can lead to nephropathy and kidney failure. There are about sixteen million diabetics in the United States and of those, about 100,000 suffer from kidney failure due to diabetes.
People with kidney failure must undergo dialysis in either of two modes or transplantation to receive a kidney from a healthy donor. Blacks, American Indians, and the descendants of Hispanic Americans have diabetes, kidney disease, and renal failure in a proportion higher than the general population. Scientists have been unable to explain this phenomenon and cannot explain fully the interplay of factors leading to diabetic nephropathy. These factors include heredity, diet, and other conditions such as hypertension.
How Stem Cell Therapy Works
Stem cells are harvested from adipose tissue or human umbilical cord tissue-derived mesenchymal stem cells, which includes fresh cells, proteins, growth factors and other tools necessary to rebuild damaged organ or tissue.
Although these substances exist naturally in an individual’s bone marrow/adipose tissue they are usually not released into a person’s bloodstream in sufficient quantities to repair damage throughout the body.
Stem cell treatments for kidney disease have not yet been developed. The kidney is a very complex organ consisting of a large number of different types of cells. To make a new kidney in the lab, all these different cells would need to be produced in a different way and mixed together in the hope that they would eventually recreate a functional kidney.
What’s more, kidney disease comes in many flavors with different cells affected and so treatments aiming to replace damaged cells within a patient’s kidney would need to supply different types of cells for different patients. Research on organ or cell replacement therapies is ongoing, but this is likely to be a long-term goal.
In the meantime, stem cells may benefit patients in other ways. For example, stem cells can be used to help progress our understanding of the disease through studies on the development and behavior of kidney cells grown in large numbers in the laboratory. Stem cell research may also enable us to utilize the body’s own repair mechanisms to find treatments for kidney disease. In acute kidney disease, the body can often repair kidney damage itself, but it is unable to do this well enough to tackle the progressive damage that occurs in chronic kidney disease. The recent identification of mesenchymal-stem-cell-like cells in the kidney may open up new possibilities for enhancing the body’s own capacity for regeneration and repair of damaged kidneys. Investigating these possibilities by studying how these newly discovered cells work is currently an important area of research. Researchers also continue to explore new ideas using emerging technologies in stem cell research, such as reprogramming cells to change their behavior.