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The Multiple Sclerosis Research Center of New York (MSRCNY) is delighted to announce the commencement of the first ever clinical trial of neural progenitor cells derived from bone marrow stem cells in the treatment of multiple sclerosis, entitled “Autologous, Bone Marrow-Derived Mesenchymal Stem Cell-Derived Neural Progenitor Cells, Expanded Ex Vivo; Administered Intrathecally.” This study was recently IRB-approved by the International Cellular Medicine Society and patient recruitment will begin in January 2012.

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This primer on stem cells is intended for anyone who wishes to learn more about the biological properties of stem cells, the important questions about stem cells that are the focus of scientific research, and the potential use of stem cells in research and in treating disease.

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Swedish scientists at the Karolinska Institutet have shown that transplanted stem cells can connect with and rescue threatened neurons and brain tissue.

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”Stem Cell Therapy may reverse Diabetes” An immune regulator from healthy cord blood stem cells ( CB SCs ) can “educate” the T cells of a person with type 1 diabetes (T1D), enabling the pancreas to produce insulin, according to a report published online January 10, 2012, in BMC Medicine – .”

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Stem Cell Information / Glossary

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In this study, we report on recent advances on the functions of embryonic, fetal, and adult stem cell progenitors for tissue regeneration and cancer therapies. We describe new procedures for derivation and maturation of these stem cells into the tissue-specific cell progenitors.

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The investigators of the Transendocardial Autologous Cells in Ischemic Heart Failure (TAC-HFT) study are now preparing a 120-patient Phase I/II trial of their technique for transendocardial injection of bone marrow-derived progenitor cells following their successful eight-patient pilot trial [1].

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Here we show that hematopoietic stem cells HSCs become liver cells when cocultured with injured liver separated by a barrier. Chromosomal analyses and tissue-specific gene and/or protein expression show that microenvironmental cues rather than fusion are responsible for conversion in vitro.

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Stem cell plasticity refers to the ability of adult stem cells to acquire mature phenotypes that are different from their tissue of origin. Adult bone marrow cells (BMCs) include two populations of bone marrow stem cells (BMCs): hematopoietic stem cells (HSCs), which give rise to all mature lineages of blood, and mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, and fat. In this article, we review the literature that lends credibility to the theory that highly plastic BMCs have a role in maintenance and repair of nonhematopoietic tissue.

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